ORGN 202 |
| This concise approach provides a very mild and efficient synthesis of D-erythro-Sphingosine with high total yield (60% in 4 steps or 75% in 6 steps) and high optical purity (>99% e.e. and 99% d.e.). In this new method, commercial available and inexpensive Serine was selected as the starting material. The total process included thio esterification, 1-OH protection, Cross Coupling, deprotection, asymmetric reduction and deprotection. |
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |