Synthesis of novel tetraazamacrocyclic antiparasitic agents

ORGN 548

David J. Robins1, Caroline M. Reid, carrei@chem.gla.ac.uk1, and Andrew Sutherland2. (1) Department of Chemistry, University of Glasgow, Glasgow, G12 8QQ, United Kingdom, (2) Department of Chemistry, WESTCHEM, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
African Sleeping Sickness is endemic in over 36 countries in sub-Saharan Africa. Current drugs are arsenic-based with severe side effects and there is a vital need for novel antiparasitic agents. A number of novel substituted tetraazamacrocycles have been synthesized using an iron template method. The compounds were tested against Trypanosoma brucei with several of the analogues displaying high activity.

 

New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006