Figure 1. Structures of examined catalysts

Scheme 1. Asymmetric transfer hydrogenation of ketones

The synthesis of novel Ru (II) catalysts 1-3 (Figure 1) for application in the asymmetric transfer hydrogenation of ketones (Scheme 1) are described, and their activity and enantioselectivity with simple ketones are investigated.

The complexes studied are characterised by chiral diamine ligands tethered to an arene moiety. The tether is placed on the a (Structure 1) or b (Structure 2) position with respect to the basic amine, or directly to it (Structure 3). The effect of diverse substituents on the arene ring in complexes of structure 3 is studied, focusing on both electronic and steric issues.