ORGN 566 |
| Pyrazole derivatives are well known biological active compounds such as anti-pyratic & anti-reheumatics, and also herbicides and fungicides. Aryl pyrazole derivatives such as Celecoxib is a well known COX-2-inhibitor used for osteoarthritis and rheumatoid arthritis. Recently some of the aryl pyrazoles have been reported to be useful in prostate cancer chemotherapy and possess non-nucleoside HIV-I reverse transcriptase inhibitory activity. Based on the above information we are interested to synthesize new types of pyrazoles. Accordingly, we synthesized the 3-methyl substituted 2,4-diketoesters for the first time, by treating ethyl ketones with NaOEt and diethyl oxalate in THF at 0 °C. The use of this diketoesters to synthesize 1,3,4 and 5 substituted pyrazoles.
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New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
