ORGN 729 |
| The bryostatins are a family of 20-membered ring macrolides, which exhibit antitumor activity. Each of the bryostatins are made up of three highly substituted tetrahydropyran rings. The C17-C27 fragment, compound 1, of bryostatin 1 is quickly and efficiently synthesized via DIBAl-H/Horner-Wadsworth-Emmons coupling and acetonide migration/glycal formation cascade. The fully elaborated core, compound 2, is completed in only 12 linear steps (15 total steps) from (R)-2-(benzyloxy)propanal. Progress toward the coupling of the northern and southern hemispheres of bryostatin 1 as well as the development of a new coupling strategy will be discussed.
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Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |
