Allosterically driven self-assembled materials

ORGN 281

Alan E. Rowan, a.rowan@science.ru.nl1, Roeland J. M. Nolte, R.Nolte@science.ru.nl2, P. J. Thomassen, P.Thomassen@science.ru.nl3, and JAAW. Elemans, J.Elemans@science.ru.nl3. (1) Institute for Molecules and Materials, Radboud University, Toernooiveld 1, Nijmegen 6525 ED, Netherlands, (2) Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands, (3) Department of Organic Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands
Allosteric assembly is a subtle technique utilized by Nature to construct hierarchical complex systems. We have recently developed a porphyrin mono-cavity and a porphyrin double-cavity, which exhibit both hetero- and homotropic allosteric behaviour. The porphyrin mono-cavity has been exploited as an exonuclease mimic. We have now utilised this unique behaviour to assemble a five-component pseudo-rotaxane and studied an allosterically controlled electron transfer process. In a second approach we have initiated the development of a new area of materials in which both polymers and defined multicomponent assemblies can be constructed by means of allosteric control. The concept, synthesis and properties of both the above systems will be discussed.

 

Materials, Molecular Recognition and Self-Assembly
8:00 AM-12:00 PM, Monday, 11 September 2006 Moscone Center -- Room 132, Oral

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006