ORGN 387 |
| The use of synthetic and designed receptors for the analysis of complex analytes in real-life settings will be presented. Analytes in beverages, blood, and chemical reactions have been targeted using a general protocol termed indicator-displacement assays. It will be shown that combinatorial receptors targeted to a class of analytes give patterns that differentiate between the individual members of the class. The strategy is to use a core binding element that imparts a bias to each and every member of the library, ensuring affinity of the library members for the class of analytes being targeted. Imparting a bias to the library dramatically reduces the diversity space needed in the library. The patterns created from the arrayed receptors are interpreted by principle component analysis or artificial neural networks. Recently, enantioselective sensing has been found to benefit from this approach. The technique represents a marriage of supramolecular chemistry and pattern recognition protocols. |
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Arthur C. Cope Award and Arthur C. Cope Scholar Awards
1:05 PM-5:05 PM, Tuesday, 12 September 2006 Moscone Center -- Room 134, Oral
Division of Organic Chemistry |