COLL 52 |
| Two drug molecules, Persantin and Propranolol, have been embedded by a sol gel process in an inorganic-organic hybrid matrix by in-situ self-assembly. The pH value in the sol-gel synthesis controls the pore size and distribution of the gels. The host-guest interaction can be tailored to control the release kinetics by appropriate choice of an organic group in the hybrid matrix. Especially the mutual interaction among aromatic groups in the host and guest is strong, and retards the dissolution process strongly. An interaction was also found between the methyl-functionalized gel surface and aromatic groups in the drug. The local molecular interaction between the drug and the host matrix has been investigated by employing two-dimensional heteronuclear correlation spectroscopy. The in vitro dissolution tests are in good agreement with results from high resolution solid-state NMR spectroscopy. The methyl and silanol groups in the matrix interact significantly with the guest molecules which controls the drug release. The results from the NMR studies provide deeper insight into the molecular level interactions between the host and the guest which will help us to design better materials for controlled drug release. |
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Advances in Nanomedicine
8:30 AM-12:20 PM, Sunday, 10 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral
Division of Colloid & Surface Chemistry |