ORGN 666 |
| Oncogenic Ras proteins, found in 20-30% of human tumors, are dependent on post-translational farnesylation for their activity. Inhibition of farnesyl transferase (FTase) has been pursued as a novel method to treat cancer. The development of ABT-100 as a potent, orally bioavailable inhibitor of FTase that is active in xenograft models will be described.
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Technical Achievements in Organic Chemistry Awards
1:40 PM-4:55 PM, Wednesday, 13 September 2006 Moscone Center -- Room 135, Oral
Division of Organic Chemistry |
