ORGN 664 |
| The quest for improved treatments of chronic pain and inflammation continues to be an area of intense research. Human bradykinin B1 receptor antagonists embody a novel approach for the treatment of these disease states. The inducible BK B1 receptor is expressed at high levels in injured tissue and is also present in the central nervous system implying the potential for a central mode of action. The synthesis of a series of antagonists possessing sub-nanomolar affinity for the human B1 receptor and acceptable pharmacokinetic properties will be described. Some novel chemistry resulting from these efforts will also be reported.
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Technical Achievements in Organic Chemistry Awards
1:40 PM-4:55 PM, Wednesday, 13 September 2006 Moscone Center -- Room 135, Oral
Division of Organic Chemistry |
