Organic synthesis and methodology for artemisinin and related natural products

ORGN 372

Gregory B. Dudley, gdudley@chem.fsu.edu, Hubert Lam, Kevin W. C. Poon, Douglas A. Engel, Jeananne A. Singletary, and Susana S. Lopez, slopez@chem.fsu.edu. Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306-4390
Artemisinin, with its unique endoperoxide pharmacophore, is a critical component of front-line malaria treatments and an experimental cancer drug. Recent advances in synthetic organic chemistry targeted towards improved access to artemisinin and related compounds will be presented, including the develepment of a gold(III)-catalyzed Meyer–Schuster rearrangement for the olefination of hindered ketones.

 

New Reactions and Methodology
8:00 AM-12:00 PM, Tuesday, 12 September 2006 Moscone Center -- Room 133, Oral

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006