COLL 109 |
| To overcome the obstacles of poor bioavailability, circulation time and cell permeability that limit the delivery and efficacy of many hydrophobic therapeutic compounds, we have designed and synthesized amphiphilic ABA-type triblock copolymers that self-assemble into nanopheres with desaminotyrosyl-tyrosine ester cores and poly(ethylene oxide) shells. These biocompatible copolymers provide a unique tunability that we exploit to obtain structure-activity relationships for a subset of nanosphere architectures and apply these to optimize their drug loading capabilities. We calculate thermodynamic solubility parameters for drugs with a range of hydrophobicities to provide an understanding of their binding and release from the nanospheres under dialysis conditions. Finally, we demonstrate that the optimized nanospheres deliver the hydrophobic anti-tumor drugs, paclitaxel and camptothecin, to human tumor cells in vitro with no loss of drug activity. |
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Advances in Nanomedicine
2:00 PM-5:30 PM, Sunday, 10 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral
Division of Colloid & Surface Chemistry |