CARB 86 |
| Heparin has been used for anticoagulant more than 50 years, but heparin has several side effects, such as development of thrombocytopenia, hemorrhagic effect and so on. The current efforts are to develop specific and potent antithrombotic agents. One abundant source of new anticoagulant is the sulfated polysaccharides from marine algae. Various anticoagulant-active polysaccharides, especially from red and brown algae, have been isolated and characterized. In our experiment lab, we are working on the anticoagulant polysaccharides from marine green algae. These anticoagulant-active polysaccharides from various green seaweeds have been isolated and characterized. The analysis results showed the polysaccharides are complex, and are composed of rhamnose, glucose, uronic acid, sulphate and small amounts xylose, galactose and mannose. 1H-NMR spectroscopic of some polysaccharides demonstrated a large peak at 1.33ppm corresponding to protons of the CH3 groups of the rhamnose residues. The mechanism of anticoagulant activity mediated by the sulfated polysaccharides from marine green algae will be investigated. |
|
Chemical Glycobiology Symposium
7:00 PM-9:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Carbohydrate Chemistry |