Chemical characterization and anticoagulant activity of sulfated polysaccharides from a marine green algae

CARB 67

Wenjun Mao, wenjunmqd@hotmail.com, Huijuan Zhang, Xiaoxue Zang, and Fang Fang. Marine Drugs and Foods Institute, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China
Marine algae are a rich source of sulfated polysaccharides with novel structures, and these compounds have anticoagulant properties. Various anticoagulant-active polysaccharides, especially from red and brown algae, have been isolated and characterized. They contain a variety of sulfated galactans and sulfated fucans. There are, however, fewer reports of anticoagulants from green algae than from brown and red algae. The green algae Ulva pertusa is consumed by local inhabitants as a marine vegetable in Shandong, China. Sulfated polysaccharides from Ulva pertusa were isolated and prepared by extraction in hot water, precipitation with ethanol and purification by ion-exchange and size-exclusion column chromatography. The characterizations of the sulfated polysaccharides were defined. The anticoagulant properties of the sulfated polysaccharides were compared with those of heparin by studying the activated partial thromboplastin time and prothrombin time using normal human plasma.
 

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8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

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8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Carbohydrate Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006