Organic synthesis using the olefin metathesis reactions

ORGN 179

Robert H. Grubbs, Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Pasadena, CA 91125
The key to the construction of many new molecular structures is the design and control of the reactivity of new catalytic complexes. The development of olefin metathesis as a new approach to the synthesis of functional structures has resulted from the development of new ligand systems that control the activity of ruthenium based system. New ligands allow reactions to be carried out in water, induce asymmetric synthesis and the construction of highly substituted carbon carbon bonds. The basis for most of these systems is the design of specifically designed N-heterocyclic carbenes.