CARB 10 |
| Heparan sulfate (HS) proteoglycans can activate various signal transduction pathways by promoting the dimerization or clustering of cell-surface receptors. We propose that HS-mediated signal transduction can be blocked by designing nanosized ligands to bind and retain multiple receptors in arrested states, a novel mode of inhibition referred to as ‘anti-clustering.' We will present our efforts to design colloidal gold nanoparticles functionalized with sulfated oligosaccharide ligands as anti-clustering agents, for the selective recruitment and orientation of HS-binding proteins such as growth factors or chemokines. Discussions will include organic synthesis and surface chemistry, which are of vital importance to the successful development of these glycosylated nanoparticles. |
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Carbohydrate Recognition Mechanisms and Applications
9:00 AM-12:15 PM, Monday, 27 March 2006 Georgia World Congress Center -- B409, Oral
Division of Carbohydrate Chemistry |