CARB 20 |
| Lectins are naturally occurring carbohydrate-binding proteins that are known to mediate various biological events. Furthermore, they are also important tools in studying the roles and functions of various glycosylations. However, the limited number and substrate specificity of lectins available restrict their applications. In this presentation, we will discuss our work in preparing boronic acid-based lectin mimics (boronolectins), which change fluorescent properties upon saccharide binding and have the potential to be “tuned” to recognize different carbohydrates. Furthermore, the platform technology allows for the preparation of a large number of such boronolectins for various in vitro and in vivo applications and should be very useful in glycomics work as well. |
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Carbohydrate Recognition Mechanisms and Applications
9:00 AM-12:15 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- B409, Oral
Division of Carbohydrate Chemistry |