Arabinose-modified siRNAs ("siANA & siFANA")

CARB 8

Masad José Damha, masad.damha@mcgill.ca1, Jonathan Watts, jonathan.watts@mail.mcgill.ca1, Nicolay Ferrari2, Tom Dowler2, Denis Bergeron2, Anna-Lisa Tedeschi2, Luc Paquet2, and Paolo Renzi2. (1) Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A2K6, Canada, (2) Topigen Pharmaceuticals, Inc, 2901 Rachel St, Suite 13, Montreal, QC H1W4A4, Canada
We present the physicochemical and biological properties of small interfering RNA duplexes (siRNA) containing arabinose modified nucleotide (ANA and FANA), as well as small interfering 2'-deoxy-2'-fluoroarabinonucleic acid(FANA):RNA hybrids for the downregulation of gene expression.
 

Implications of Sugar Ring Conformations in Drug Design: A Symposium in Memory of Muttaiya Sundaralingam
9:00 AM-12:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- B409, Oral

Division of Carbohydrate Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006