CARB 40 |
| Bacillus anthracis, the etiological agent of anthrax, is most commonly found in wild and domestic lower vertebrates. Humans can also contract the disease upon exposure to infected animals and their tissues or by inhaling anthrax spores. B. anthracis spores cannot easily be detected or identified. In order to effectively confront the threat of anthrax spores as a biological weapon, it is imperative that problems concerning anthrax diagnosis, vaccination, therapy, post exposure prophylaxis, and decontamination of the environment will be addressed. Recently, the structure of a novel oligosaccharide (1) isolated from the glycoprotein Bc1A of the exosporium of the B. anthracis was elucidated. In order to evaluate the antigenicity and significance of this cell-wall carbohydrate as diagnostic marker and/or vaccine component, a convergent synthesis of spacer-linked oligosaccharide 2 was developed. Protein-conjugates of the tetrasaccharide were prepared and used in immunization studies.
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General Posters
6:00 PM-8:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Carbohydrate Chemistry |
