CARB 41 |
| A novel synthetic methodology has been developed for the construction of a three-component synthetic anti-cancer vaccine candidate by native chemical ligation. The vaccine candidate constitutes the minimal structural features required for an effective T-cell dependent immune response and is composed of a carbohydrate B-epitope, a peptide T-epitope and a lipopeptide adjuvant. Lipidation of the antigen facilitated the incorporation into liposomes, which in turn improved the presentation of the immunogen to the immune system. Immunological properties of the liposomes have been studied. |
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General Posters
6:00 PM-8:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Carbohydrate Chemistry |