CARB 34 |
| Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, is among the most potent proinflammatory substances known, with its lipid A region initiating the production of multiple host-derived inflammatory mediators that may initiate the clinical symptoms of septic shock. The lipid A region of LPS induces these responses by interacting with the Toll-like receptor 4 (TLR4)/MD2 complex on the surface of mononuclear phagocytes. Immediately distal to TLR4 activation are two intracellular cascades, which employ the adaptor protein MyD88 or TRIF. Recent studies have indicated that LPS of E. coli O55:B5 primarily stimulates the MyD88-dependent pathway, while the LPS of S. typhimurium mainly utilizes the TRIF-pathway. To achieve an understanding of the structural features required for MyD88- and TRIF-dependent cellular activation, several lipid A analogues of E. coli lipid A and S. typhimurium lipid A have been synthesized and their inflammatory properties determined. |
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General Posters
6:00 PM-8:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Carbohydrate Chemistry |