CARB 12 |
| Compounds that can interfere in the biosynthesis of oligosaccharides may offer potential as therapeutics for a wide range of diseases. We have developed a general approach for the design of selective glycosidase inhibitors based on feedback inhibition. In this approach, a pro-drug is converted into an active inhibitor by the action of a targeted glycosidase. The exquisite selectivity of glycosidases for their substrates assures that high selectivity is achieved. The approach has been applied for the development of a selective inhibitor of Golgi Mannosidase II, which is a target for cancer therapy development. |
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Carbohydrate Recognition Mechanisms and Applications
9:00 AM-12:15 PM, Monday, 27 March 2006 Georgia World Congress Center -- B409, Oral
Division of Carbohydrate Chemistry |