Polyfuran-based long-wavelength fluorescent boronic acids for carbohydrate sensing

CARB 52

Jun Yan, Shan Jin, wang@gsu.edu, Arvind Kumar, akumar@gsu.edu, David W. Boykin, dboykin@gsu.edu, and Binghe Wang, wang@gsu.edu. Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303
Boronic acids are known to bind carbohydrates via reversible covalent interactions with the diol functional groups present. Such interactions have been used for the preparation of fluorescent sensors for carbohydrates. Critical to this effort is the availability of boronic acids that change fluorescent properties upon sugar binding. Particularly desirable are boronic acids that fluoresce at long wavelengths (above 500 nm). This presentation will discuss the design and synthesis of polyfuran-based boronic acids, which fluoresce in the visible light region. Such compounds will be very useful for the preparation of fluorescent carbohydrate sensors and lectin mimics.
 

General Posters
6:00 PM-8:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Carbohydrate Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006