I&EC 136 |
| Hofmeister series is a list of ions in an order of their abilities in stabilizing proteins based on their kosmotropicity. It has been well established that kosmotropic anions and chaotropic cations stabilize proteins, while chaotropic anions and kosmotropic cations destabilize them. Many studies also concluded that the same principle is applicable to the enzyme stabilization in aqueous solutions. Hydrophilic ionic liquids dissociate into individual ions in aqueous environment. Therefore, the effect of ionic liquids on the enzyme activity and stability can be correlated to the individual contributions from cations and anions. This hypothesis was examined and supported by our data on the protease activity, stability and enantioselectivity in aqueous solutions of ionic liquids with varying degrees of kosmotropicity of cations and anions. Our preliminary finding indicated that Hofmeister series could be an empirical guideline for choosing ionic liquids for enzymatic reactions in aqueous solutions. |
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Ionic Liquids: Not Just Solvents Anymore OR Ionic Liquids: Parallel Futures (Sponsored by Green Chemistry and Engineering, Separation Science and Technology and Novel Chemistry with Industrial Applications Sub-Divisions)
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Industrial and Engineering Chemistry |