CARB 13 |
| Sugars are critical biological markers that modulate the properties of proteins. Our work studies the interplay of proteins and sugars. This lecture will discuss recent developments our laboratory in two areas: (i) glycoprotein & glycoconjugate synthesis – the use of glycosylation to modulate function; and (ii) carbohydrate-processing enzyme mechanism – the engineering, study and use of glycosidases & glycosyltransferases and the synthesis of probes of their mechanism. (i) Glycoprotein & glycoconjugate synthesis: Precisely glycosylated enzymes & proteins can be used in • preparative biocatalysis • drug delivery • selective protein degradation. New classes of glycoconjugate, glycodendriprotein and glycoviruses act as powerful nanomolar inhibitors of bacterial interactions or gene delivery vehicles, respectively. Antioxidant glycopolymers enhance cellular lifetimes and enhance function. (ii) Carbohydrate-Processing Enzymes: Glycosidases and glycosylatransferases are powerful synthetic catalysts. Mutants and novel glycomimetic syntheses illuminate substrate selection and catalytic mechanisms.
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Carbohydrate Recognition Mechanisms and Applications
9:00 AM-12:15 PM, Monday, 27 March 2006 Georgia World Congress Center -- B409, Oral
Division of Carbohydrate Chemistry |
