Towards mimics of the aminosugars found in the capsular polysaccharides of S. aureus types 5 and 8

CARB 28

Abdul-Basit Alhassan, pnorris@ysu.edu, Sara Duncan, Mathew Maust, pnorris@ysu.edu, Matthias Zeller, mzeller@cc.ysu.edu, and Peter Norris, pnorris@ysu.edu. Department of Chemistry, Youngstown State University, 1 University Plaza, Youngstown, OH 44555
The protective capsular polysaccharides that coat S. aureus types 5 and 8 contain the rare aminosugars N-acetyl-D-mannosamine uronic acid, N-acetyl-D-fucosamine, and N-acetyl-L-fucosamine. We are interested in producing analogs of these sugars that may be capable of disrupting the biosynthesis of the individual sugars and the construction of the capsular polysaccharides. An approach to N-acetyl-L-fucosamine from L-rhamnose will be presented along with our efforts on mimics of each of the enantiomeric fucosamines.
 

General Posters
6:00 PM-8:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Carbohydrate Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006