Microwave synthesis of substituted benzimidazole derivatives

CHED 433

Jasmin Courtney, jcourtney@spelman.edu and Leyte Winfield, lwinfield@spelman.edu. Department of Chemistry, Spelman College, 350 Spelman LN, SW, Box 231, Atlanta, GA 30314
The synthesis of benzimidazole derivatives, potential anti-proliferative agents, is initiated by the preparation of a diaryl amine. The ring formation can be completed by two different procedures. One method employs a reduction step followed by a condensation reaction. Alternatively, there can be a one-pot reaction to generate the ring. Both methods can be enhanced by microwave synthesis. Here the complete microwave synthesis for the benzimidazole molecule will be presented.