CHED 374 |
| Self-assembly is an attractive synthetic strategy for the construction of sensitive, reliable and cheap fluorescent probes for metal cations. Guanosine and related compounds have a propensity to form planar tetramers (tetrads), which are held together by H-bonds and cation complexation; further stacking of such tetrads leads to G-quadruplex formation. We will present the synthesis of 3'- and 5'-(pyrenyl-labeled)-8-phenyl-2'-deoxyguanosine analogues as well as studies of their photophysical properties before and after their self-assembly templated by a variety of metal cations (See figure below). The fluorescence properties of these probes are modulated by the supramolecular structure as supported by fluorescence and NMR spectroscopies. These results bode well for development of sensors for metal cations for biomedical and environmental applications.
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Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, 27 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Chemical Education |
