Development of a new synthetic method for substituted 4-hydroxyisoquinolines

CHED 377

Colin J. Kubarych, Chemistry and Biochemistry, University of Tulsa, 600 S. College Ave., Tulsa, OK 74104 and John C. DiCesare, john-dicesare@utulsa.edu, Department of Chemistry and Biochemistry, The University of Tulsa, 600 South College Ave, Tulsa, OK 74104.
The subject of this presentation is the synthesis of substituted 4-hydroxyisoquinolines, which are anti-cancer drug precursors. Our goal is to synthesize the nitrogen ring using simple molecules to create a synthetic method that is both inexpensive and highly effective. Currently, our research involves the use of simple aromatic aldehydes and ketones along with amino acid derivatives to synthesize the compound. By using these simple compounds, we can use starting materials that are cost effective as well as molecules that contain other functionalities with in the molecule. A highly functionalized starting material will allow us to modify the 4-hydroxyisoquinoline structure. The reaction conditions are also studied to determine the most efficient process for cyclization. Our most recent advancements towards the final target will be presented
 

Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, 27 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Chemical Education

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006