CHED 385 |
| This research involved modification and structural study of nucleosides and DNA oligomers by measuring the infrared (IR) absorption of a novel probe – a nitrile group. Indirectly, this method also provides a measure of the electronic environment of the nucleic acid species through the vibrational Stark effect (VSE). The syntheses of the CN–substituted nucleoside targets, including derivatives containing isotopic carbon and nitrogen in the nitrile group, were accomplished and their characteristic IR absorptions identified. Several nitrile–modified DNA oligomers have been prepared and studied. For example, a nitrile–guanosine substituted into thrombin aptamer DNA was found to undergo a large Stark shift from its monomeric absorption frequency.
|
|
Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, 27 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Chemical Education |
