Green amination reactions in subcritical water: A modified Leuckart reaction

CHED 400

Cory Gaiser1, Michael Howart1, J. Michael Gibson2, and Jessica L. Tischler, jtisch@umflint.edu1. (1) Department of Chemistry, University of Michigan-Flint, 303 E. Kearsely St., Flint, MI 48502, (2) Department of Chemistry & Physics, Wingate University, Campus Box 3053, Wingate, NC 28174
Traditional reductive amination requires hydrogenation or hydride reducing agents. Additionally, acid catalysts and organic solvents are required. This study will examine a modified Leuckart reaction using formamides as both the nitrogen donor and reducing agent. Solvation and acid catalysis will be provided by water at subcritical conditions. A series of substituted formamides was studied with short chain, long chain, and aromatic aldehydes.
 

Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, 27 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Chemical Education

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006