DNA cleavage by radicals photo-generated from aryl sulfoxides

CHED 384

Daniel J Mayo, dm0769@ship.edu and Allison H. Predecki, ahpred@ship.edu. Department of Chemistry, Shippensburg University, 1871 Old Main Drive, Shippensburg, PA 17257

Aryl sulfoxides have the ability to photoinduce single strand cleavage of plasmid DNA.  An investigation of this cleavage has been performed using the simple, commercially available compounds, phenyl sulfoxide and methyl phenyl sulfoxide.  Preliminary mechanistic studies indicate that carbon radicals are responsible for this cleavage.