Green synthesis of substituted 1,2,3-triazoles (student)

CHED 402

Cathleen Raikevitch and Cynthia Kellen-Yuen, ckyuen@csus.edu. Department of Chemistry, California State University, Sacramento, 6000 J Street, Sacramento, CA 95819-6057
Triazoles, which can be found in agrochemicals, photochemical products, antifungal drugs, and pharmaceutical substances, are of interest as synthons for amide linkages. They can be synthesized through a 1,3-dipolar cycloaddition reaction. The syntheses of a variety of substituted 1,2,3-triazoles were carried out via a “Green” synthetic method, more specifically in the absence of solvent or catalyst, and using a domestic microwave oven. The synthetic method chosen proved to be a fast and efficient technique to obtain triazoles in good to excellent yields and has been shown to be an interesting alternative to the classical synthesis, without the use of toxic and environmentally unsafe compounds.