ORGN 411 |
| We recently described a new approach for the stabilization of artificial alpha-helices that involves replacement of one of the main chain hydrogen bonds with a carbon-carbon bond derived from a ring-closing metathesis reaction. The salient feature of this hydrogen-bond surrogate (HBS) approach is that it affords constrained alpha-helices without restricting access to the molecular recognition surfaces or altering the side chain functionalities. We have found that these HBS alpha-helices can target chosen protein receptor with high affinity. This poster will discuss the relationship between macrocycle structure and helicity, and regulation of apoptosis by these artificial helices.
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New Reactions and Methodology, Bioorganic Chemistry, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Sci-Mix
Division of Organic Chemistry |
