ORGN 96 |
| Efforts towards fostriecin are presented, focusing on two different tether-mediated desymmetrization strategies. In the first synthetic pathway, a tripodal coupling/multivalent activation strategy is utilized to assemble the key bicyclic phosphate, followed by selective reaction and cleavage methods. Overall, the phosphate moiety serves a multi-faceted role as a tether, leaving group, and protecting group. In the second approach, another variation on desymmetrization employing monosilylation, directed epoxidation and RCM presents a streamlined approach towards the natural product. Each pathway allows for myriad modifications and variations en route to fostriecin-like library development.
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Sci-Mix
Division of Organic Chemistry |
