ORGN 489 |
| Intramolecular rhodium(II)-catalyzed C–H amination has found increasing application in complex molecule synthesis due to the efficiency and selectivity of this process. The recent development of an intermolecular C–H amination reaction greatly enhances the utility of this chemistry. This process uses the starting alkane as the limiting reagent, gives optically pure tetrasubstituted amines through stereospecific insertion of enantiomeric 3° centers, and displays high chemoselectivity for benzylic oxidation. Access to substituted amines, amino alcohols, and diamines is thereby made possible in a single transformation. The evolution of this methodology along with mechanistic insights that have been gained through analytical studies of the intermolecular reaction will be discussed.
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Metal-Mediated Reactions and Syntheses
1:00 PM-5:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- C302, Oral
Division of Organic Chemistry |
