ORGN 541 |
| Gingkolides are considered the main neuromodulatory components of Ginkgo biloba extract. The minor and not easily accessible components of the ginkgolide fraction of the extract, such as ginkgolide J and ginkgolide M, have been shown to be potent compounds in modulating the pathological pathways leading to neurodegenerative disorders. We report facile and convenient synthetic approaches leading to sufficient quantities of ginkgolides J and M. The developed chemistry provides means to probe functional and structural diversity-oriented approaches using the ginkgolide scaffold.
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Heterocycles, Aromatics, Metal-Mediated Reactions and Syntheses, Materials, Devices, and Switches
8:00 PM-10:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |
