ORGN 476 |
| Progress toward the synthesis of the densely functionalized antibiotic pactamycin (3) will be described. In one approach, 2-methylcyclopentenone (1) was transformed into the oxygenated core (2) by a twelve step route (approx 18% overall yield) that features stereoselective osmylation and epoxidation steps.
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Total Synthesis of Complex Molecules
1:00 PM-5:20 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- C301, Oral
Division of Organic Chemistry |
