Studies towards the total synthesis of (-)-dictyostatin

ORGN 484

Frauke Pohlki, fpohlki@bu.edu, Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 24 Cummington Street, Boston, MA 02115 and James S. Panek, panek@chem.bu.edu, Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 24 Cummington Street, Boston, MA 02215.
Studies towards the synthesis of (-)-dictyostatin, a potent cytotoxic macrolide from the marine sponge of the genus Spongia sp. will be presented. Identification of syn- and anti-related oxygen-methyl vicinal stereochemical relationships suggested that the polypropionate-like units could be achieved through double stereodifferentiating crotylation reactions, a valuable extension of chiral organosilane methodology developed in our laboratories.

 

Total Synthesis of Complex Molecules
1:00 PM-5:20 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- C301, Oral

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006