ORGN 547 |
| The environmentally benign synthesis of β-amino carbonyl compounds via tandem nitro-reduction/Mannich reactions is being investigated. β-Amino carbonyl compounds are biologically and synthetically important compounds, having wide applications in the synthesis of numerous pharmaceuticals and natural products. A unique feature of this reaction is the recycling of indium (III) byproducts of the nitro reduction step as catalysts for imine formation and subsequent condensation. Each step of this reaction has been explored individually; however, combining nitro reduction with imine formation and reaction with the silylketene acetal in a one-pot synthesis has not been reported. We will report our progress investigating this domino synthesis, along with reaction optimization efforts. |
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Heterocycles, Aromatics, Metal-Mediated Reactions and Syntheses, Materials, Devices, and Switches
8:00 PM-10:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Sci-Mix
Division of Organic Chemistry |