ORGN 570 |
| Formation and control of carbon-carbon bonds are an essential part of organic synthesis. The ability to also dictate regioselectivity during these formations is an important step in controlling the structure of natural products and synthetic templates. Indium metal has historically shown to add preferentially to unsaturated carbonyl moieties with 1,2- preference over a 1,4-addition pathway. This poster will address studies in our laboratory revealing that indium promoted couplings to propargyl aldehydes may be controlled to give the 1,2-, or 1,4-addition product. Slight modifications to these conditions also allow formation of the 6-membered ring lactol as shown in Scheme 1.
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Heterocycles, Aromatics, Metal-Mediated Reactions and Syntheses, Materials, Devices, and Switches
8:00 PM-10:00 PM, Wednesday, 29 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |
