High load soluble oligomeric triphenylphosphine: Applications in organic synthesis

ORGN 132

Thiwanka Samarakoon, smtikiri@mail.ku.edu1, Andrew M. Harned, aharned@ku.edu1, Paul R. Hanson, phanson@ku.edu1, and Daniel L. Flynn, dflynn@deciphera.com2. (1) Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr, NIH Center of Excellence in Chemical Methodologies and Library Development (KU-CMLD), Lawrence, KS 66045-7582, (2) Deciphera Pharmaceuticals LLC, 4950 Research Park Way, Lawrence, KS 66047
Efforts towards the utilization of oligomeric soluble triphenylphosphine (OTTP) for functional group transformation is presented. Generation of the functionalized norbornenyl-based triphenylphosphine monomer followed by ROM polymerization utilizing Grubbs metathesis catalysts provides soluble oligomeric triphenylphosphine (OTPP) of different lengths and tunable properties. The utilsation of OTPP in a variety of synthetic transformations is presented.

 

Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006