High–load ROMP-derived oligomers with tunable properties: Applications in library generation

ORGN 135

Punitha Vedantham, punithav@ku.edu1, Jennifer Guerra, jguerra@ku.edu1, Parul J Gor1, Mianji Zhang, mizhang@ku.edu1, Maria del Sol Jiménez, msjimenz@ku.edu1, Gunda I. Georg, georg@ku.edu2, and Paul R Hanson, phanson@ku.edu1. (1) Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Malott Hall, NIH Center of Excellence in Chemical Methodologies and Library Development (KU-CMLD), Lawrence, KS 66045-7582, (2) Department of Medicinal Chemistry, Kansas University, 4001 Malott Hall, 1251 Wescoe Hall Drive, Lawrence, KS 66045
Efforts towards the implementations of high-load ROMP-derived oligomers with tunable properties for production of medium-sized libraries are presented. The scaffolds generated are: (1) cyclic sulfamide heterocycles and (2) potential methionine aminopeptidase inhibitors. A general coupling protocol using ROMP-derived DCC with different benzylic, aromatic, secondary amines, sulfonamides, heterocyclic amines and alcohols to provide the corresponding products has been accomplished. Currently we are investigating a catch-release strategy to generate a library of substituted aryl-furoic acid and aryl-thiophene carboxylic acids.
 

Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Organic Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006