ORGN 97 |
| Current progress towards the dolabelide class of natural products via functionally active phosphate tethers (P-tethers) is described. The dolabelide family of natural products represents a class of potent poly-ketide based macrolactones that exhibit a wide range of biological activity. We have recently reported the formation of P-chiral bicyclic phosphates via a terminus differentiation strategy utilizing RCM for the desymmetrization of phosphate tethered 1,3-anti-diols. This study focuses on the extension of this chemistry to the specific generation of both the northern and southern portions of dolabelide via both antipodes of the 1,3-anti-diol derived bicyclic phosphates.
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |
