ORGN 107 |
| The study of the charge-transport (CT) properties of DNA has received much attention in the recent years because of the promising applications of DNA in nano-electronics and due to the role such electron transfer reactions play in DNA damage. The efficiency of charge transport across the stacked base pairs of DNA is mainly dependent on the sequence and hence the nature and rates of charge transport vary in different DNA oligomers. Generally, these electron transfer reactions are probed by analysis of the distribution of strand cleavage products, which is related to the rates of the charge hopping and trapping reactions. When the energy barrier is low, the charge is expected to become distributed across the DNA much faster than it is trapped by reaction with water or O2. In the present study we have examined the charge transfer properties of a series of DNA oligomers, where the G-steps are separated by single base bridges and in some cases compounds that have one or more additional charge traps. The results show that these systems provide a good example for the pseudo-distance independent charge transport in DNA where the charge injected is being distributed over the DNA leading to equal reaction at all potential sites. |
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |