Investigation of a novel double barrelled Heck reaction involving pyrroles

CHED 416

Courtney E. Rogers, rogersce@hendrix.edu1, Christina N. Barnes, goodwin@hendrix.edu1, Daniel Z. Liu, Goodwin@hendrix.edu1, Thomas E. Goodwin, goodwin@hendrix.edu1, and Martin G. Banwell2. (1) Department of Chemistry, Hendrix College, 1600 Washington Ave, Conway, AR 72032, (2) Research School of Chemistry, The Australian National University, Canberra, ACT 0200, Australia
Banwell et al. (Aust. J. Chem., 1998, 52, 755) reported a unique “double-barrelled” Heck cyclization (1 to 2) to prepare an analog of the potent lamellarin class of anti-cancer, marine natural products (C. Bailly, Curr. Med. Chem.-Anti-Cancer Agents, 2004, 4, 363). We are investigating a related and unprecedented approach in which the halogens reside on the pyrrole ring. Synthesis of pyrrole precursors, development of cross-coupling conditions, and progress toward lamellarin analogs will be reported.

 

Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, 27 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Chemical Education

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006