ORGN 157 |
| Spirastrellolide A, a novel macrolide isolated from the marine sponge Spirastrella coccinea, has been demonstrated to be a potent and selective inhibitor of protein phosphatase 2A (IC50 = 1nM). Key intermediates are envisioned to be synthesized by implementing methodology previously discovered in our laboratory. Our convergent design provides an efficient and flexible approach that will enable a rapid assembly of the C1-C15 fragment, and allow easy access to the desired diastereomers. |
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |