ORGN 168 |
| The enatioslective synthesis of Goniothalamin Oxide has been achieved in 5 steps from achiral cinnamaldehyde. The route relies upon a diastereoselective Leighton allylation to establish the desired C-5 stereochemistry. This route also relies on a ring-closing metathesis to establish the α,β-unsaturated lactone and a hydroxyl- directed epoxidation to stereoselectively install the epoxide. Our efforts to combine Goniothalamin Oxide with Altholactone to form Goniolactone A are ongoing and our latest results will be discussed.
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |
