ORGN 136 |
| Our research goal is to make a dynamic combinatorial library using amino acids derivatives as building blocks. The components of the library are made by reversible olefin cross metathesis using Grubb's catalyst 2nd generation. We first synthesized amino acids with a terminal olefin moiety. We then synthesized the homodimers via Grubb's 2nd generation in good yields. We are now testing our amino acids derivatives as basic components for dynamic combinatorial librairies, and different templates are being examinated to select and amplify one compound from the equilibrating mixtures. |
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Asymmetric Reactions and Syntheses, Physical Organic Chemistry, Combinatorial Chemistry, Total Synthesis
8:00 PM-10:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Division of Organic Chemistry |