ORGN 318 |
| Palladium-catalyzed alpha-arylation of zinc enolates of esters and amides will be presented. Methods have been developed using three different sources of zinc enolates. The reaction scope has been greatly expanded and a large number of alpha-aryl esters and amides can be synthesized using a variety of aryl bromides under mild conditions. The catalytic systems used are a mixture of palladium precursor and the hindered ligand pentaphenylferrocenyl di-tert-butylphosphine (Q-phos) or the highly reactive dimeric Pd(I) complex {[P(tert-Bu)3]PdBr}2.
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New Reactions and Methodology, Bioorganic Chemistry, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, 28 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Sci-Mix
Division of Organic Chemistry |
